Patarapotikul J, Langsley G
Unit of Experimental Parasitology, Institut Pasteur, Paris, France.
Nucleic Acids Res. 1988 May 25;16(10):4331-40. doi: 10.1093/nar/16.10.4331.
The P. falciparum pPFrep20 repetitive element from the Palo Alto Uganda strain has been isolated and sequenced. The Palo Alto pPFrep20 repeat (pPFPArep20) has a clustered subtelomeric location and on chromosome 1 has been deleted from one end. Analysis of chromosome 1 from 5 other strains has revealed that pPFrep20 sequences have been deleted from one end in 3 of them. Thus, deletion of pPFrep20 appears to be a frequent event that could significantly contribute to chromosome size polymorphism in P. falciparum.
来自乌干达帕洛阿尔托菌株的恶性疟原虫pPFrep20重复元件已被分离并测序。帕洛阿尔托pPFrep20重复序列（pPFPArep20）具有成簇的亚端粒位置，并且在1号染色体上一端已被删除。对其他5个菌株的1号染色体分析表明，其中3个菌株的pPFrep20序列一端已被删除。因此，pPFrep20的删除似乎是一个常见事件，可能对恶性疟原虫染色体大小多态性有显著贡献。
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