Novartis Pharma and Novartis Institutes for Biomedical Research, Basel, Switzerland and Cambridge, Massachusetts, USA.
Kenya Medical Research Institute (KEMRI)/Strathmore University (SU), Nairobi, Kenya.
Clin Pharmacol Ther. 2017 Nov;102(5):786-795. doi: 10.1002/cpt.695. Epub 2017 Jun 5.
A strong scientific rationale exists for conducting clinical pharmacology studies in target populations because local factors such as genetics, environment, comorbidities, and diet can affect variability in drug responses. However, clinical pharmacology studies are not widely conducted in sub-Saharan Africa, in part due to limitations in technical expertise and infrastructure. Since 2012, a novel public-private partnership model involving research institutions and a pharmaceutical company has been applied to developing increased capability for clinical pharmacology research in multiple African countries.
在目标人群中开展临床药理学研究具有坚实的科学依据，因为遗传、环境、合并症和饮食等局部因素会影响药物反应的变异性。然而，临床药理学研究在撒哈拉以南非洲地区并未广泛开展，部分原因是技术专业知识和基础设施有限。自 2012 年以来，一种涉及研究机构和制药公司的新型公私合作伙伴关系模式已被应用于提高多个非洲国家临床药理学研究能力。
