父母患有抑郁症和双相情感障碍的子女中出现的心境恶劣障碍。
Disruptive mood dysregulation disorder in offspring of parents with depression and bipolar disorder.
机构信息
Lukas Propper, MD, Department of Psychiatry, Dalhousie University, Halifax and Department of Psychiatry, IWK Health Centre, Halifax, Nova Scotia; Jill Cumby, RN, Victoria C. Patterson, BA (Hons), Vladislav Drobinin, BSc, Jacqueline M. Glover, BSc, Lynn E. MacKenzie, MA, Jessica Morash-Conway, MA, Nova Scotia Health Authority, Halifax, Nova Scotia, Sabina Abidi, MD, Alexa Bagnell, MD, David Lovas, MD, Department of Psychiatry, Dalhousie University, Halifax and Department of Psychiatry, IWK Health Centre, Halifax, Nova Scotia; Tomas Hajek, MD, Department of Psychiatry, Dalhousie University, Halifax and Nova Scotia Health Authority, Halifax, Nova Scotia; William Gardner, PhD, Children's Hospital of Eastern Ontario, Ottawa and Department of Epidemiology, University of Ottawa, Ottawa, Ontario; Kathleen Pajer, MD, Children's Hospital of Eastern Ontario, Ottawa and Department of Psychiatry, University of Ottawa, Ottawa, Ontario; Martin Alda, MD, Department of Psychiatry, Dalhousie University, Halifax and Nova Scotia Health Authority, Halifax, Nova Scotia; Rudolf Uher, PhD, Department of Psychiatry, Dalhousie University, Halifax, Department of Psychiatry, IWK Health Centre, Halifax and Nova Scotia Health Authority, Halifax, Nova Scotia, Canada.
Lukas Propper, MD, Department of Psychiatry, Dalhousie University, Halifax and Department of Psychiatry, IWK Health Centre, Halifax, Nova Scotia; Jill Cumby, RN, Victoria C. Patterson, BA (Hons), Vladislav Drobinin, BSc, Jacqueline M. Glover, BSc, Lynn E. MacKenzie, MA, Jessica Morash-Conway, MA, Nova Scotia Health Authority, Halifax, Nova Scotia, Sabina Abidi, MD, Alexa Bagnell, MD, David Lovas, MD, Department of Psychiatry, Dalhousie University, Halifax and Department of Psychiatry, IWK Health Centre, Halifax, Nova Scotia; Tomas Hajek, MD, Department of Psychiatry, Dalhousie University, Halifax and Nova Scotia Health Authority, Halifax, Nova Scotia; William Gardner, PhD, Children's Hospital of Eastern Ontario, Ottawa and Department of Epidemiology, University of Ottawa, Ottawa, Ontario; Kathleen Pajer, MD, Children's Hospital of Eastern Ontario, Ottawa and Department of Psychiatry, University of Ottawa, Ottawa, Ontario; Martin Alda, MD, Department of Psychiatry, Dalhousie University, Halifax and Nova Scotia Health Authority, Halifax, Nova Scotia; Rudolf Uher, PhD, Department of Psychiatry, Dalhousie University, Halifax, Department of Psychiatry, IWK Health Centre, Halifax and Nova Scotia Health Authority, Halifax, Nova Scotia, Canada
出版信息
Br J Psychiatry. 2017 Jun;210(6):408-412. doi: 10.1192/bjp.bp.117.198754. Epub 2017 Apr 6.
It has been suggested that offspring of parents with bipolar disorder are at increased risk for disruptive mood dysregulation disorder (DMDD), but the specificity of this association has not been established.We examined the specificity of DMDD to family history by comparing offspring of parents with (a) bipolar disorder, (b) major depressive disorder and (c) a control group with no mood disorders.We established lifetime diagnosis of DMDD using the Schedule for Affective Disorders and Schizophrenia for School Aged Children for DSM-5 in 180 youth aged 6-18 years, including 58 offspring of parents with bipolar disorder, 82 offspring of parents with major depressive disorder and 40 control offspring.Diagnostic criteria for DMDD were met in none of the offspring of parents with bipolar disorder, 6 of the offspring of parents with major depressive disorder and none of the control offspring. DMDD diagnosis was significantly associated with family history of major depressive disorder.Our results suggest that DMDD is not specifically associated with a family history of bipolar disorder and may be associated with parental depression.
有人认为，父母患有双相情感障碍的子女患破坏性情绪失调障碍（DMDD）的风险增加，但这种关联的特异性尚未确定。我们通过比较父母患有（a）双相情感障碍、（b）重性抑郁障碍和（c）无心境障碍的对照组的子女，来研究 DMDD 对家族史的特异性。我们使用用于 DSM-5 的儿童和青少年情绪障碍和精神分裂症的时间表，对 180 名年龄在 6-18 岁的青少年进行了 DMDD 的终生诊断，其中包括 58 名父母患有双相情感障碍的子女、82 名父母患有重性抑郁障碍的子女和 40 名对照组子女。患有双相情感障碍父母的子女中无一例符合 DMDD 的诊断标准，而患有重性抑郁障碍父母的子女中有 6 例符合 DMDD 的诊断标准，对照组子女中无一例符合。DMDD 的诊断与重性抑郁障碍的家族史显著相关。我们的结果表明，DMDD 与双相情感障碍的家族史并无特异性关联，而可能与父母的抑郁有关。
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