福斯高林或肌醇作为锂中毒解毒剂无效。简短报告。
Lack of effectiveness of forskolin or inositol as antidote in lithium toxicity. Short note.
作者信息
Kaplan Z, Schreiber G, Belmaker R H
机构信息
Ida and Solomon Stern Psychiatric Research Unit, Beer Sheva Mental Health Center, Israel.
出版信息
J Neural Transm. 1988;72(2):167-70. doi: 10.1007/BF01250239.
PMID:2838582
Abstract
Forskolin, a direct adenylate cyclase stimulator, was suggested as a possible antidote to lithium toxicity, since lithium inhibits cyclic AMP accumulation. Inositol, a sugar isomer reduced in lithium treatment due to inhibition of inositol-1-phosphatase, was suggested as a possible antidote to lithium toxicity. Both were ineffective in a mouse model.
摘要
毛喉素是一种直接的腺苷酸环化酶刺激剂，由于锂会抑制环磷酸腺苷（cAMP）的积累，它被认为可能是锂中毒的一种解毒剂。肌醇是一种糖异构体，在锂治疗中因肌醇-1-磷酸酶受到抑制而减少，它也被认为可能是锂中毒的一种解毒剂。但在小鼠模型中，这两种物质均无效。
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