使用 Charlson 合并症指数评估特应性皮炎成人患者的主要合并症。

Assessment of major comorbidities in adults with atopic dermatitis using the Charlson comorbidity index.

机构信息

Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.

出版信息

J Am Acad Dermatol. 2017 Jun;76(6):1088-1092.e1. doi: 10.1016/j.jaad.2017.01.030. Epub 2017 Apr 6.

DOI:10.1016/j.jaad.2017.01.030

PMID:28392292

Abstract

BACKGROUND

There is a growing interest in comorbidities of adults with atopic dermatitis (AD).

OBJECTIVES

To examine the burden of comorbidities in adult patients with AD using the Charlson comorbidity index (CCI) in nationwide registries.

METHODS

All Danish patients ≥18 years on January 1, 2012 with AD diagnosed by a hospital dermatologist were included. Patients were age-and sex-matched in a 1:4 ratio with general population controls. Severity was determined by systemic AD treatment and analyzed by conditional logistic regression.

RESULTS

In total, 10,738 adult patients with AD and 42,952 controls were analyzed. CCI score was significantly increased in smokers with AD compared with controls (0.41 vs 0.13, P < .001). Nonsmokers with AD had a similar CCI score as controls (0.09 vs 0.08, P = .12). In analyses restricted to patients with severe AD, a stronger difference in CCI score was observed for smokers (0.48 vs 0.14, P < .001) than for nonsmokers (0.10 vs 0.08, P = .01).

LIMITATIONS

Observational studies do not establish cause and effect.

CONCLUSION

On the basis of nationwide data, the risk for major comorbidities was significantly increased in adult patients with AD compared with controls. The risk difference was predominantly found in patients with severe disease and among smokers.

摘要

背景

成人特应性皮炎（AD）合并症日益受到关注。

目的

使用 Charlson 合并症指数（CCI）在全国性登记处评估成年 AD 患者的合并症负担。

方法

纳入 2012 年 1 月 1 日年龄≥18 岁、由皮肤科医生诊断为 AD 的所有丹麦患者。患者按照年龄和性别以 1:4 的比例与一般人群对照匹配。严重程度通过全身 AD 治疗确定，并通过条件逻辑回归进行分析。

结果

共分析了 10738 例成年 AD 患者和 42952 例对照。与对照组相比，吸烟的 AD 患者的 CCI 评分明显升高（0.41 比 0.13，P<0.001）。不吸烟的 AD 患者的 CCI 评分与对照组相似（0.09 比 0.08，P=0.12）。在仅对严重 AD 患者进行的分析中，吸烟者的 CCI 评分差异更为显著（0.48 比 0.14，P<0.001），而非吸烟者差异较小（0.10 比 0.08，P=0.01）。