Xu Z F, Li X D, Wu Y X, Tai J, Zhang Y M, Peng X X, Zheng L, Shi J, Ni X
Department of Respiratory, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
Department of Otorhinolaryngology, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017 Mar 7;52(3):220-224. doi: 10.3760/cma.j.issn.1673-0860.2017.03.011.
To investigate the characteristics of sleep-related respiratory events in normal children and to provide normal polysomnographic parameters for diagnosing sleep-disordered breathing in children. Normal subjects between 3 and 14 years old were enrolled from 1 July 2014 to 31 December 2015 and the subjects received overnight polysomnography at the sleep center of our hospital. They were children of our hospital employees or were recruited from the communities who did not have sleep and respiratory disorders. The children were divided into preschool group (3-5 years) and school-age group (6-14 years). Apnea index (AI), obstructive apnea index (OAI), central apnea index (CAI), and mixed apnea index (MAI) were compared between the two groups. Data for continuous variables that showed normal distribution were expressed as x ±. (, ) were used when data were not normally distributed. Continuous variables that showed normal distribution were compared by using an independent-sample t-test. Wilcoxon-test was performed when data exhibited non-normal distribution. Differences in categorical data were tested with Chi-square test. correlation test was applied for the correlation analysis. <0.05 was considered statistically significant. A total of 115 normal children took part in the study including 40 in preschool group and 75 in school-age group. Children in both groups had a few sleep apnea events, most of which were central apneas, accounting for 80% and 70% of the total respiratory events respectively. Central apnea index in preschool children were significantly higher than that of school-age children (<0.001), with median of 0.6 times/h and 0.1 times/h, respectively. Median OAI of both groups were 0.0 times/h without significant difference (=0.748). Obstructive apnea events occurred mainly in the supine position in both groups. Normal children may have a few apnea events in sleep that were predominantly central apnea. CAI of preschool children is significantly higher than that of school-age children. Obstructive sleep apnea is rare in normal children, and sleep apnea occurs mainly in the supine position.
探讨正常儿童睡眠相关呼吸事件的特征,为儿童睡眠呼吸障碍的诊断提供正常的多导睡眠图参数。选取2014年7月1日至2015年12月31日期间3至14岁的正常受试者,在我院睡眠中心接受整夜多导睡眠监测。受试者为我院职工子女或从无睡眠及呼吸障碍的社区招募而来。将儿童分为学龄前组(3至5岁)和学龄组(6至14岁)。比较两组的呼吸暂停指数(AI)、阻塞性呼吸暂停指数(OAI)、中枢性呼吸暂停指数(CAI)和混合性呼吸暂停指数(MAI)。呈正态分布的连续变量数据以x±表示。数据非正态分布时用(,)表示。呈正态分布的连续变量采用独立样本t检验进行比较。数据呈非正态分布时进行Wilcoxon检验。分类数据的差异采用卡方检验。采用相关性检验进行相关分析。P<0.05认为差异有统计学意义。共有115名正常儿童参与研究,其中学龄前组40名,学龄组75名。两组儿童均有少量睡眠呼吸暂停事件,其中大部分为中枢性呼吸暂停,分别占总呼吸事件的80%和70%。学龄前儿童的中枢性呼吸暂停指数显著高于学龄儿童(P<0.001),中位数分别为0.6次/小时和0.1次/小时。两组的OAI中位数均为0.0次/小时,无显著差异(P=0.748)。两组阻塞性呼吸暂停事件均主要发生于仰卧位。正常儿童睡眠中可能有少量呼吸暂停事件,主要为中枢性呼吸暂停。学龄前儿童的CAI显著高于学龄儿童。正常儿童阻塞性睡眠呼吸暂停罕见,且睡眠呼吸暂停主要发生于仰卧位。