免疫介导的细胞因子风暴及其在严重登革热中的作用。
Immune-mediated cytokine storm and its role in severe dengue.
作者信息
Srikiatkhachorn Anon, Mathew Anuja, Rothman Alan L
机构信息
Institute for Immunology and Informatics, University of Rhode Island, 80 Washington St., Rm 302F, Providence, RI, 02903, USA.
出版信息
Semin Immunopathol. 2017 Jul;39(5):563-574. doi: 10.1007/s00281-017-0625-1. Epub 2017 Apr 11.
Abstract
Dengue remains one of the most important mosquito-borne diseases worldwide. Infection with one of the serologically related dengue viruses (DENVs) can lead to a wide range of clinical manifestations and severity. Severe dengue is characterized by plasma leakage and abnormal bleeding that can lead to shock and death. There is currently no specific treatment for severe dengue due to gaps in understanding of the underlying mechanisms. The transient period of vascular leakage is usually followed by a rapid recovery and is suggestive of the effects of short-lived biological mediators. Both the innate and the adaptive immune systems are activated in severe dengue and contribute to the cytokine production. We discuss the immunological events elicited during a DENV infection and identify candidate cytokines that may play a key role in the severe manifestations of dengue and possible interventions.
摘要
登革热仍然是全球最重要的蚊媒疾病之一。感染血清学相关的登革病毒（DENV）之一可导致广泛的临床表现和严重程度。重症登革热的特征是血浆渗漏和异常出血，可导致休克和死亡。由于对潜在机制的理解存在差距，目前尚无针对重症登革热的特异性治疗方法。血管渗漏的短暂时期通常随后迅速恢复，这提示了短期生物介质的作用。重症登革热中固有免疫系统和适应性免疫系统均被激活，并促进细胞因子的产生。我们讨论了DENV感染期间引发的免疫事件，并确定了可能在登革热严重表现中起关键作用的候选细胞因子以及可能的干预措施。
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