蓝斑中的GABAA和GABAB受体：阻断剂的作用
GABAA and GABAB receptors in locus coeruleus: effects of blockers.
作者信息
Olpe H R, Steinmann M W, Hall R G, Brugger F, Pozza M F
机构信息
Biology Research Laboratories, Ciba-Geigy Ltd., Basle, Switzerland.
出版信息
Eur J Pharmacol. 1988 Apr 27;149(1-2):183-5. doi: 10.1016/0014-2999(88)90061-1.
Racemic baclofen, (-)-baclofen and muscimol depressed all spontaneously firing locus coeruleus neurons tested in a slice preparation. Racemic phaclofen (100 microM; 1 mM) moderately antagonized the effects of racemic baclofen without antagonizing those of muscimol. Bicuculline (10, 30, 100 microM) potently antagonized the action of muscimol without affecting the inhibition of baclofen. Phaclofen and bicuculline had no pronounced effect on the spontaneous discharge rate of cells. The results suggests that there are GABAA and GABAB receptors in the locus coeruleus.
消旋巴氯芬、(-)-巴氯芬和蝇蕈醇抑制了在脑片制备中测试的所有自发放电的蓝斑神经元。消旋法氯芬（100微摩尔；1毫摩尔）适度拮抗消旋巴氯芬的作用，但不拮抗蝇蕈醇的作用。荷包牡丹碱（10、30、100微摩尔）有效拮抗蝇蕈醇的作用，而不影响巴氯芬的抑制作用。法氯芬和荷包牡丹碱对细胞的自发放电率没有明显影响。结果表明蓝斑中存在GABAA和GABAB受体。
Zotero 插件