豚鼠坐骨神经中分枝杆菌肉芽肿引起的神经损伤。
Nerve damage induced by mycobacterial granulomas in guinea pig sciatic nerves.
作者信息
Cowley S A, Butter C, Verghese S, Curtis J, Turk J L
机构信息
Department of Pathology, Royal College of Surgeons of England, London.
出版信息
Int J Lepr Other Mycobact Dis. 1988 Jun;56(2):283-90.
A possible model for nerve damage in leprosy has been developed in the sciatic nerve of the guinea pig. Intraneural injection of 10(7) BCG organisms into an unsensitized animal induces an epithelioid cell granuloma in 2 weeks similar to that found in tuberculoid leprosy patients. In contrast, intraneural injection of 10(9) cobalt-irradiated Mycobacterium leprae organisms induces a macrophage granuloma in 5 weeks, similar to that found in lepromatous leprosy patients. Histological, immunohistochemical, electron microscopical and electrophysiological studies have demonstrated that the lesions induced in the experimental animals show many of the features documented in studies of nerve damage in leprosy patients.
在豚鼠的坐骨神经中已建立了一种麻风病神经损伤的可能模型。向未致敏的动物神经内注射10⁷ 个卡介苗生物体，2周后会诱发上皮样细胞肉芽肿，类似于结核样麻风病患者中发现的肉芽肿。相比之下，向神经内注射10⁹ 个经钴照射的麻风分枝杆菌生物体，5周后会诱发巨噬细胞肉芽肿，类似于瘤型麻风病患者中发现的肉芽肿。组织学、免疫组织化学、电子显微镜和电生理学研究表明，实验动物中诱发的病变表现出许多在麻风病患者神经损伤研究中记录的特征。
Zotero 插件