Assessing cumulative acute toxicity of chemoradiotherapy in head and neck cancer with or without induction chemotherapy.
作者信息
Shah Bhartesh A, Qureshi Muhammad M, Logue Jennifer M, Cooley Timothy P, Zaner Ken S, Jalisi Scharukh, Truong Minh Tam
机构信息
Department of Radiation Oncology, Boston Medical Center, Boston University School of Medicine, Boston, MA, United States.
Section of Hematology and Oncology, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, MA, United States.
出版信息
Am J Otolaryngol. 2017 Jul-Aug;38(4):456-461. doi: 10.1016/j.amjoto.2017.04.004. Epub 2017 Apr 12.
BACKGROUND
To compare cumulative acute toxicity in head and neck cancer patients treated with concurrent chemoradiotherapy alone (CCRT) versus induction chemotherapy (IC) followed by CCRT (I/CCRT).
METHODS
77 patients underwent definitive CCRT (30 I/CCRT and 47 CCRT). Toxicity was graded using the Common Terminology Criteria for Adverse Events version 4.0. Using the TAME adverse event reporting system, short-term toxicity (T) scores were generated for IC (T), CCRT (T), total treatment duration (T), post-treatment period (T) and an overall score (T) from treatment start to post treatment period.
RESULTS
Acute toxicity other than dysphagia, odynophagia, or dermatitis was reported in 90.0% and 66.0% of I/CCRT and CCRT patients, respectively (P=0.02). Compared to CCRT group, I/CCRT patients reported greater mean T (T: 2.11 vs. 2.87, P=0.01) and T (T: 2.60 vs. 3.70, P=0.003).
CONCLUSION
I/CCRT patients reported more cumulative acute toxicity during treatment compared to CCRT patients using the TAME reporting system.
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