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两名年轻的格陵兰原住民脊髓损伤后制动引起的高钙血症影响肾功能。

Immobilisation-induced hypercalcemia following spinal cord injury affecting the kidney function in two young native Greenlanders.

作者信息

Linstow Michael V, Biering-Sørensen Fin

机构信息

Clinic for Spinal Cord Injuries, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

出版信息

Spinal Cord Ser Cases. 2017 Apr 13;3:17010. doi: 10.1038/scsandc.2017.10. eCollection 2017.

Abstract

INTRODUCTION

Immobilisation-induced hypercalcemia following SCI affecting the kidney function, is a rare but potentially serious condition. We report immobilisation-induced hypercalcemia affecting the kidney function in two young native Greenlanders with spinal cord injury (SCI).

CASE PRESENTATIONS

Two 15- and 24-year-old male native Greenlanders, both with traumatic C5 SCI were admitted to our spinal cord unit. They were non-smokers without history of daily alcohol intake pre- or immediately post-injury. No physical demanding activities pre-injury. Due to complaints of nausea/vomiting 10-12 weeks post-injury, not explained by usual causes such as urinary tract infection, blood samples were drawn and hypercalcaemia found. Both patients started treatment including increased hydration. Within 1 month calcium ion, plasma-creatinine and plasma-carbamide were normalised.

DISCUSSION

Over the last 20 years our spinal cord unit has only experienced immobilisation-induced hypercalcemia following SCI affecting the kidney function in two young male native Greenlanders. This finding of immobilisation-induced hypercalcemia following SCI affecting the kidney function in two young native Greenlanders, but not in the rest of our primary native Danish patient population, also including youngsters, suggests that ethnicity may be a pre-disposing factor.

摘要

引言

脊髓损伤后因制动导致的高钙血症影响肾功能,是一种罕见但可能严重的病症。我们报告了两名患有脊髓损伤(SCI)的年轻格陵兰原住民因制动导致的影响肾功能的高钙血症病例。

病例介绍

两名15岁和24岁的格陵兰原住民男性,均因创伤性C5脊髓损伤入住我们的脊髓病房。他们不吸烟,受伤前或受伤后即刻均无每日饮酒史。受伤前无体力要求高的活动。因受伤后10 - 12周出现恶心/呕吐症状,且排除了诸如尿路感染等常见病因,遂采集血样并发现高钙血症。两名患者均开始接受包括增加补液量在内的治疗。1个月内钙离子、血浆肌酐和血浆尿素水平恢复正常。

讨论

在过去20年里,我们的脊髓病房仅在两名年轻的格陵兰原住民男性中遇到过脊髓损伤后因制动导致的影响肾功能的高钙血症病例。在两名年轻的格陵兰原住民中发现脊髓损伤后因制动导致的影响肾功能的高钙血症,但在我们其余包括年轻人在内的丹麦本土主要患者群体中未发现,这表明种族可能是一个易感因素。

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