非编码 RNA 在肝细胞癌中的作用：机制、生物标志物和治疗靶点。
Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets.
机构信息
Division of RNA Biology & Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany; Hartmut Hoffmann-Berling International Graduate School of Molecular and Cellular Biology (HBIGS), University of Heidelberg, Heidelberg, Germany.
Department of Transplantation, Mayo Clinic, Jacksonville, FL, USA; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.
出版信息
J Hepatol. 2017 Sep;67(3):603-618. doi: 10.1016/j.jhep.2017.04.009. Epub 2017 Apr 22.
The majority of the human genome is not translated into proteins but can be transcribed into RNA. Even though the resulting non-coding RNAs (ncRNAs) do not encode for proteins, they contribute to diseases such as cancer. Here, we review examples of the functions of ncRNAs in liver cancer and their potential use for the detection and treatment of liver cancer.
人类基因组的大部分并未翻译成蛋白质，但可以转录成 RNA。即使由此产生的非编码 RNA（ncRNA）不编码蛋白质，它们也会导致癌症等疾病。在这里，我们回顾了 ncRNA 在肝癌中的作用及其在肝癌检测和治疗中的潜在用途的例子。
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