经治非小细胞肺癌组织学样本的再次活检：再次活检程序之间的比较
Rebiopsy of Histological Samples in Pretreated Non-small Cell Lung Cancer: Comparison Among Rebiopsy Procedures.
作者信息
Hata Akito, Katakami Nobuyuki, Nanjo Shigeki, Okuda Chiyuki, Kaji Reiko, Imai Yukihiro
机构信息
Division of Integrated Oncology, Institute of Biomedical Research and Innovation Hospital, Kobe, Japan
Division of Integrated Oncology, Institute of Biomedical Research and Innovation Hospital, Kobe, Japan.
出版信息
In Vivo. 2017 May-Jun;31(3):475-479. doi: 10.21873/invivo.11086.
AIM
The aim of the present study was to compare successful rate, failure reasons, and complications among procedures of histological rebiopsy.
PATIENTS AND METHODS
We retrospectively reviewed medical records of histologically rebiopsied cases with non-small cell lung cancer.
RESULTS
One hundred and eleven histological rebiopsies were performed in: 86 (77%) lung; 11 (10%) lymph node; 5 (5%) pleura; 4 (4%) liver; 2 (2%) muscle; 2 (2%) adrenal gland; and 1 (1%) rib. Successful rate by computed tomography-guided biopsy (CTGB), transbronchial biopsy (TBB), and ultrasound-guided biopsy were 86% (48/56), 90% (28/31), and 100% (24/24), respectively. Reasons for rebiopsy failure by CTGB were no/insufficient malignant cells (n=5) and pneumothorax (n=3), and those by TBB were no/insufficient malignant cells (n=2) and bleeding (n=1). Severe complications (≥grade 3): one grade 3 pneumothorax and one grade 4 air embolization were observed in two (2%, 2/111) cases receiving CTGB.
CONCLUSION
Rebiopsy of histological samples can be highly successful and feasible by optimal procedural selection.
目的
本研究旨在比较组织学再次活检程序的成功率、失败原因及并发症。
患者与方法
我们回顾性分析了非小细胞肺癌组织学再次活检病例的医疗记录。
结果
共进行了111次组织学再次活检，部位包括：肺86例（77%）；淋巴结11例（10%）；胸膜5例（5%）；肝4例（4%）；肌肉2例（2%）；肾上腺2例（2%）；肋骨1例（1%）。计算机断层扫描引导下活检（CTGB）、经支气管活检（TBB）和超声引导下活检的成功率分别为86%（48/56）、90%（28/31）和100%（24/24）。CTGB再次活检失败的原因是无/恶性细胞不足（n = 5）和气胸（n = 3），TBB的原因是无/恶性细胞不足（n = 2）和出血（n = 1）。严重并发症（≥3级）：在接受CTGB的2例（2%，2/111）患者中观察到1例3级气胸和1例4级空气栓塞。
结论
通过优化程序选择，组织学样本再次活检可取得高成功率且可行。
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