Dalebroux Zachary D
Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
J Bacteriol. 2017 Jun 13;199(13). doi: 10.1128/JB.00136-17. Print 2017 Jul 1.
In this issue of the , V. W. Rowlett et al. unveil new circuitry linking membrane glycerophospholipid (GPL) homeostasis to bacterial stress response and adaptation mechanisms (J Bacteriol 199:e00849-16, 2017, https://doi.org/10.1128/JB.00849-16). Glycerophospholipids comprise critical components of the dual-membrane envelope of Gram-negative bacteria and participate in many processes. The new evidence suggests that, in some instances, distinct GPL molecules function for distinct biochemistry and bacteria sense perturbations in membrane GPL concentrations to coordinate survival strategies. Understanding GPL sensing and remodeling mechanisms will be important moving forward, given the breadth of function for these molecules in bacteriology.
在本期《》杂志中,V. W. 罗利特等人揭示了将膜甘油磷脂(GPL)稳态与细菌应激反应及适应机制联系起来的新信号通路(《细菌学杂志》199:e00849 - 16, 2017, https://doi.org/10.1128/JB.00849-16)。甘油磷脂是革兰氏阴性菌双膜包膜的关键组成部分,并参与许多过程。新证据表明,在某些情况下,不同的GPL分子具有不同的生物化学功能,并且细菌能够感知膜GPL浓度的扰动以协调生存策略。鉴于这些分子在细菌学中的广泛功能,了解GPL感知和重塑机制对于未来的研究将很重要。