轮状病毒引起的新生犊牛腹泻
Neonatal calf diarrhea induced by rotavirus.
作者信息
Castrucci G, Frigeri F, Ferrari M, Cilli V, Gualandi G L, Aldrovandi V
机构信息
Istituto di Malattie Infettive, Profilassi e Polizia Veterinaria dell'Università di Perugia, Italy.
出版信息
Comp Immunol Microbiol Infect Dis. 1988;11(2):71-84. doi: 10.1016/0147-9571(88)90021-5.
This presentation summarizes the results of a comprehensive study on rotaviruses isolated in Italy from calves and rabbits affected by neonatal diarrhea. The results clearly indicated that rotavirus infection is widespread and supported the evidence for an etiologic role of these viruses in neonatal diarrhea. The evidence of differences in virulence among bovine rotaviruses appeared also to be confirmed. Conventionally reared calves were fully susceptible to the experimental infection induced by three rotaviruses originating from heterologous hosts, i.e. monkeys, pigs and rabbits, respectively. When rotavirus strains of bovine, simian, porcine and rabbit origin were compared by cross neutralization tests, it was found the simian and porcine strains were indistinguishable and both appeared to relate antigenically to the bovine strain. On the other hand, a reciprocal antigenic correlation was found between bovine and rabbit isolates. Finally, it was proven that feeding newborn calves with colostrum of their dams, previously vaccinated with an inactivated rotavirus vaccine, could prevent the neonatal diarrhea from occurring.
本报告总结了一项关于从意大利患新生儿腹泻的犊牛和兔子中分离出的轮状病毒的综合研究结果。结果清楚地表明轮状病毒感染广泛存在，并支持了这些病毒在新生儿腹泻中作为病因的证据。牛轮状病毒之间毒力差异的证据似乎也得到了证实。常规饲养的犊牛对分别源自异源宿主（即猴子、猪和兔子）的三种轮状病毒引起的实验性感染完全易感。当通过交叉中和试验比较牛、猴、猪和兔源的轮状病毒株时，发现猴源和猪源毒株无法区分，且二者在抗原性上似乎都与牛源毒株相关。另一方面，在牛源和兔源分离株之间发现了相互的抗原相关性。最后，事实证明，用先前接种过灭活轮状病毒疫苗的母畜的初乳喂养新生犊牛，可以预防新生儿腹泻的发生。
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