阿米卡星单独或与氯法齐明或利福布汀或两者联合应用对米色小鼠急性实验性鸟分枝杆菌复合群感染的体内活性。
In vivo activity of amikacin alone or in combination with clofazimine or rifabutin or both against acute experimental Mycobacterium avium complex infections in beige mice.
作者信息
Gangadharam P R, Perumal V K, Podapati N R, Kesavalu L, Iseman M D
机构信息
National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206.
出版信息
Antimicrob Agents Chemother. 1988 Sep;32(9):1400-3. doi: 10.1128/AAC.32.9.1400.
Abstract
The in vivo activity of amikacin, used alone or in combination with rifabutin or clofazimine or both, was assessed in the treatment of early and established Mycobacterium avium complex infections in beige mice. Amikacin given alone at a dose of 50 mg/kg, in one, two, or three divided doses, showed remarkable activity. Addition of clofazimine increased the activity significantly, but addition of the third drug, rifabutin, did not further improve the results. Amikacin-containing regimens are worthy of consideration for investigations in patients with M. avium complex infections.
摘要
在米色小鼠中评估了单独使用阿米卡星或与利福布汀或氯法齐明或两者联合使用时，对鸟分枝杆菌复合群早期和已确诊感染的体内活性。单独给予剂量为50mg/kg的阿米卡星，分1、2或3次给药，显示出显著活性。添加氯法齐明可显著提高活性，但添加第三种药物利福布汀并未进一步改善结果。含阿米卡星的治疗方案值得在鸟分枝杆菌复合群感染患者中进行研究。
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