Department of Chemistry, Yale University , 275 Prospect Street, New Haven, Connecticut 06520-8107, United States.
Chem Rev. 2017 Sep 27;117(18):11680-11752. doi: 10.1021/acs.chemrev.6b00833. Epub 2017 May 19.
First-row transition-metal-mediated reactions constitute an important and growing area of research due to the low cost, low toxicity, and exceptional synthetic versatility of these metals. Currently, there is considerable effort to replace existing precious-metal-catalyzed reactions with first-row analogs. More importantly, there are a plethora of unique transformations mediated by first-row metals, which have no classical second- or third-row counterpart. Herein, the application of first-row metal-mediated methods to the total synthesis of natural products is discussed. This Review is intended to highlight strategic uses of these metals to realize efficient syntheses and highlight the future potential of these reagents and catalysts in organic synthesis.
由于这些金属的低成本、低毒性和出色的综合多功能性，第一过渡金属介导的反应构成了一个重要且不断发展的研究领域。目前，人们正在努力用第一过渡金属类似物替代现有的贵金属催化反应。更重要的是，有大量由第一过渡金属介导的独特转化，这些转化没有经典的第二或第三过渡金属对应物。本文讨论了第一过渡金属介导的方法在天然产物全合成中的应用。本综述旨在强调这些金属在实现高效合成中的战略用途，并突出这些试剂和催化剂在有机合成中的未来潜力。
