从班氏地胆草中分离得到的巨大戟烷型糖苷。

Megastigmane glucosides isolated from Dichrocephala benthamii.

作者信息

Song Bo, Si Jin-Guang, Yu Meng, Tian Xiao-Hui, Ding Gang, Zou Zhong-Mei

机构信息

Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China.

Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China; Henan University of Traditional Chinese Medicine, Zhengzhou 450016, China.

出版信息

Chin J Nat Med. 2017 Apr;15(4):288-291. doi: 10.1016/S1875-5364(17)30046-8.

DOI:10.1016/S1875-5364(17)30046-8

PMID:28527514

Abstract

The present study was designed to investigate the chemical constituents of the whole herb of Dichrocephala benthamii. A new megastigmane glucoside (compound 1), together with its four known analogues (compounds 2-5), was obtained. Their structures were elucidated on the basis of spectroscopic analyses (UV, IR, MS, and 1D and 2D NMR). The absolute configuration of compound 1 was assigned on the basis of CD method and chemical evidence. In addition, their cytotoxicity against human hepatoma cells (HepG-2) was evaluated by the MTT method. Compound 5 showed weak activity against HepG-2, while the other compounds did not show remarkable inhibitory effects.

摘要

本研究旨在对白花地胆草全草的化学成分进行研究。从中分离得到了一个新的巨大戟烷型糖苷（化合物1）及其四个已知类似物（化合物2 - 5）。通过光谱分析（紫外光谱、红外光谱、质谱以及一维和二维核磁共振谱）对其结构进行了鉴定。基于圆二色光谱法和化学证据确定了化合物1的绝对构型。此外，采用MTT法评估了它们对人肝癌细胞（HepG - 2）的细胞毒性。化合物5对HepG - 2显示出较弱的活性，而其他化合物未显示出明显的抑制作用。