Salemi Arash, Worku Berhane M
Department of Cardiothoracic Surgery, Weill Cornell Medicine/New York Presbyterian Hospital, New York, NY, USA.
Departmemt of Cardiothoracic Surgery, New York Presbyterian Brooklyn Methodist Hospital, Brooklyn, NY, USA.
J Thorac Dis. 2017 Apr;9(Suppl 4):S289-S298. doi: 10.21037/jtd.2017.03.114.
Transcatheter aortic valve replacement (TAVR) has become a widely accepted therapeutic option for patients with severe, symptomatic aortic stenosis at intermediate, high, or extreme risk for conventional surgery as determined through a heart team approach. Two valve prostheses are currently available and the Food and Drug Administration (FDA) approved in the United States for TAVR: the self-expandable Medtronic CoreValve (Medtronic, Inc., Minneapolis, MN, USA) and the balloon-expandable Edwards Sapien Valve (Edwards Lifesciences, Irvine CA, USA). The preoperative evaluation for TAVR includes transthoracic echocardiography (TTE) for the diagnosis of aortic stenosis. Cardiac computed tomography (CTA) has become the imaging modality of choice for annular sizing. Aortic root dimensions and coronary ostia height, and the degree of annular and left ventricular outflow tract calcification are also assessed to estimate the risk of coronary obstruction, annular rupture, and postoperative aortic regurgitation. Finally, CTA is essential to determine the adequacy of the peripheral vasculature for a transfemoral approach. Intraoperatively, fluoroscopy is mandatory for valve positioning, whereas the use of TTE or transesophageal echocardiography (TEE) varies by center. TTE is used for postoperative surveillance of valve function.
经导管主动脉瓣置换术(TAVR)已成为一种广泛接受的治疗选择,适用于通过心脏团队评估确定为传统手术中、高或极高风险的重度症状性主动脉瓣狭窄患者。目前有两种瓣膜假体可供使用,并且已获得美国食品药品监督管理局(FDA)批准用于TAVR:自膨胀式美敦力CoreValve(美敦力公司,美国明尼苏达州明尼阿波利斯)和球囊膨胀式爱德华兹Sapien瓣膜(爱德华兹生命科学公司,美国加利福尼亚州欧文)。TAVR的术前评估包括经胸超声心动图(TTE)以诊断主动脉瓣狭窄。心脏计算机断层扫描(CTA)已成为测量瓣环大小的首选成像方式。还需评估主动脉根部尺寸、冠状动脉开口高度以及瓣环和左心室流出道钙化程度,以估计冠状动脉阻塞、瓣环破裂和术后主动脉瓣反流的风险。最后,CTA对于确定经股动脉入路时外周血管系统是否合适至关重要。术中,透视是瓣膜定位所必需的,而TTE或经食管超声心动图(TEE)的使用因中心而异。TTE用于术后瓣膜功能监测。