病毒发病机制的变异性：对急性和持续性感染动态进行建模
Variability in viral pathogenesis: modeling the dynamic of acute and persistent infections.
作者信息
Lidsky Peter V, Andino Raul, Rouzine Igor M
机构信息
Department of Microbiology and Immunology, University of California, San Francisco, United States.
Department of Microbiology and Immunology, University of California, San Francisco, United States.
出版信息
Curr Opin Virol. 2017 Apr;23:120-124. doi: 10.1016/j.coviro.2017.05.001. Epub 2017 May 25.
Virus infection often results in diverse outcomes. This variability of virus pathogenesis is not well understood. Here we revise theoretical arguments to further our understanding of factors controlling infection and its severity. We propose that variability in these factors results in different clinical outcomes, which ultimately ensure virus reproduction.
病毒感染常常导致多种结果。病毒发病机制的这种变异性尚未得到充分理解。在此，我们修正理论观点以进一步加深我们对控制感染及其严重程度的因素的理解。我们提出，这些因素的变异性导致不同的临床结果，而这些结果最终确保病毒的繁殖。
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