Kowalik Marta Anna, Columbano Amedeo, Perra Andrea
Department of Biomedical Sciences, Unit of Oncology and Molecular Pathology, University of Cagliari, Cagliari, Italy.
Front Oncol. 2017 May 11;7:87. doi: 10.3389/fonc.2017.00087. eCollection 2017.
In recent years, there has been a revival of interest in metabolic changes of cancer cells as it has been noticed that malignant transformation and metabolic reprogramming are closely intertwined. The pentose phosphate pathway (PPP) is one of the fundamental components of cellular metabolism crucial for cancer cells. This review will discuss recent findings regarding the involvement of PPP enzymes in several types of cancer, with a focus on hepatocellular carcinoma (HCC). We will pay considerable attention to the involvement of glucose-6-phosphate dehydrogenase, the rate-limiting enzyme of the PPP. Subsequently, we discuss the inhibition of the PPP as a potential therapeutic strategy against cancer, in particular, HCC.
近年来，随着人们注意到恶性转化与代谢重编程紧密相连，对癌细胞代谢变化的兴趣再度兴起。磷酸戊糖途径（PPP）是细胞代谢的基本组成部分之一，对癌细胞至关重要。本综述将讨论关于PPP酶在几种癌症类型中的作用的最新发现，重点是肝细胞癌（HCC）。我们将特别关注PPP的限速酶葡萄糖-6-磷酸脱氢酶的作用。随后，我们讨论抑制PPP作为一种针对癌症尤其是HCC的潜在治疗策略。
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