心肌缺血期间异丙肾上腺素诱导的心脏产热作用的逆转。
Reversal of isoproterenol-induced calorigenic action in the heart during myocardial ischemia.
作者信息
Juhász-Nagy A, Kékesi V, Papp L
机构信息
Cardiovascular Surgical Clinic, Semmelweis University Medical School, Budapest, Hungary.
出版信息
Acta Biol Hung. 1988;39(1):31-8.
With the aid of infrared thermography, a powerful new tool for studying the biological state of cardiac regulatory mechanisms, the reversal of the isoproterenol-induced calorigenic action in the in situ dog heart was demonstrated after establishing acute myocardial ischemia. The thermographic manifestations indicated a modified activity pattern of the cardiac (coronary) beta-mechanism with a preserved sensitivity to its specific pharmacologic blockade. Results provide new evidence of the transformation (plasticity) of adrenoceptor qualities under pathologic circumstances.
借助红外热成像技术这一研究心脏调节机制生物学状态的强大新工具，在建立急性心肌缺血模型后，证实了原位犬心脏中异丙肾上腺素诱导的产热作用发生了逆转。热成像表现表明心脏（冠状动脉）β机制的活动模式发生了改变，但其对特定药理学阻断的敏感性得以保留。研究结果为病理情况下肾上腺素能受体特性的转变（可塑性）提供了新证据。
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