饮酒与心力衰竭风险：13 项前瞻性研究的荟萃分析。
Alcohol consumption and risk of heart failure: Meta-analysis of 13 prospective studies.
机构信息
Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
出版信息
Clin Nutr. 2018 Aug;37(4):1247-1251. doi: 10.1016/j.clnu.2017.05.007. Epub 2017 May 19.
BACKGROUND & AIMS: Controversy exists on the association between alcohol consumption and risk of heart failure (HF). We carried out a meta-analysis to summarize available prospective data on alcohol consumption and HF.
METHODS
We searched PubMed for relevant studies published until January 1, 2017. Relative risk (RR) estimates from individual studies were pooled in a random-effects meta-analysis.
RESULTS
A total of 13 prospective studies, with 13,738 HF cases and 355,804 participants, were included in the meta-analysis. Light alcohol drinking (0.1-7 drinks/week) was inversely associated with risk of HF (RR, 0.86; 95% confidence interval, 0.81-0.90). There was no statistically significant association between moderate (7.1-14 drinks/week), high (14.1-28 drinks/week), or heavy (>28 drinks/week) alcohol consumption and HF risk. Former drinking was associated with an increased risk of HF compared with never or occasional drinking (RR, 1.22; 95% confidence interval, 1.11-1.33).
CONCLUSIONS
This meta-analysis found that light alcohol drinking was associated with a lower risk of HF. Former drinking was associated with a higher risk of HF.
背景与目的
关于饮酒与心力衰竭（HF）风险之间的关联存在争议。我们进行了荟萃分析，以总结关于饮酒与 HF 的现有前瞻性数据。
方法
我们在 PubMed 上搜索了截至 2017 年 1 月 1 日发表的相关研究。个体研究的相对风险（RR）估计值在随机效应荟萃分析中进行了汇总。
结果
荟萃分析共纳入了 13 项前瞻性研究，涉及 13738 例 HF 病例和 355804 名参与者。轻度饮酒（每周 0.1-7 杯）与 HF 风险呈负相关（RR，0.86；95%置信区间，0.81-0.90）。中度（每周 7.1-14 杯）、高度（每周 14.1-28 杯）或重度（每周>28 杯）饮酒与 HF 风险之间无统计学显著关联。与从不饮酒或偶尔饮酒相比，既往饮酒与 HF 风险增加相关（RR，1.22；95%置信区间，1.11-1.33）。
结论
本荟萃分析发现，轻度饮酒与 HF 风险降低相关。既往饮酒与 HF 风险增加相关。
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