Mooij Christiaan F, van Alfen-van der Velden Janiëlle A E M, Netea-Maier Romana T, Ten Broek Roel, Gotthardt Martin, Hagleitner Melanie M
Division of Pediatric Oncology.
Division of Pediatric Endocrinology, Amalia Children's Hospital.
J Pediatr Hematol Oncol. 2018 Mar;40(2):145-147. doi: 10.1097/MPH.0000000000000869.
We report the case of a 16-year-old female patient with hypothyroidism, goiter, and pancytopenia. Biopsy of the thyroid showed leukemic infiltration. After confirmation of the diagnosis of B-lymphoblastic leukemia, treatment was started. Histologic follow-up at day 33 and 79 showed no residual signs of leukemic infiltration. Hypothyroidism persisted despite successful antileukemic treatment. Leukemic infiltration of the thyroid should be considered as a differential diagnosis in patients with hypothyroidism, goiter, and pancytopenia. We suggest that follow-up of thyroid function and histology should be incorporated in the follow-up of rare patients with acute lymphoblastic leukemia with thyroid infiltration.
我们报告了一例16岁患有甲状腺功能减退、甲状腺肿和全血细胞减少症的女性患者。甲状腺活检显示有白血病浸润。在确诊为B淋巴细胞白血病后，开始进行治疗。第33天和第79天的组织学随访显示无白血病浸润的残留迹象。尽管抗白血病治疗成功，但甲状腺功能减退仍持续存在。甲状腺白血病浸润应被视为甲状腺功能减退、甲状腺肿和全血细胞减少症患者的鉴别诊断。我们建议，对于罕见的伴有甲状腺浸润的急性淋巴细胞白血病患者的随访，应纳入甲状腺功能和组织学的随访。
Zotero 插件