铜催化的偕二氟烯烃与 Bpin 的立体选择性硼化反应。
Cu-Catalyzed Stereoselective Borylation of gem-Difluoroalkenes with Bpin.
机构信息
Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology (ECUST) , Shanghai 200237, China.
出版信息
Org Lett. 2017 Jun 16;19(12):3283-3286. doi: 10.1021/acs.orglett.7b01430. Epub 2017 Jun 5.
PMID:28581762
Abstract
A novel and efficient method for the synthesis of (Z)-fluorinated alkenylboronic acid pinacol esters via Cu-catalyzed stereoselective borylation of gem-difluoroalkenes using bis(pinacolato)diboron (Bpin) as the boron source with the assistance of NaOtBu and Xantphos at room temperature was developed.
摘要
开发了一种通过 Cu 催化的立体选择性硼化作用，使用双（频哪醇）二硼（Bpin）作为硼源，在室温下使用 NaOtBu 和 Xantphos 辅助，从 (Z)-氟化烯基硼酸频哪醇酯通过 Cu 催化的立体选择性硼化作用，使用双（频哪醇）二硼（Bpin）作为硼源，在室温下使用 NaOtBu 和 Xantphos 辅助，从 (Z)-氟化烯基硼酸频哪醇酯
Zotero 插件