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1999-2013 年 Medicare 受益人群肺动脉导管的使用和结局的全国趋势。

National Trends in Use and Outcomes of Pulmonary Artery Catheters Among Medicare Beneficiaries, 1999-2013.

机构信息

Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.

Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, Connecticut.

出版信息

JAMA Cardiol. 2017 Aug 1;2(8):908-913. doi: 10.1001/jamacardio.2017.1670.

Abstract

IMPORTANCE

Recent studies have observed an increase in the rate of pulmonary artery catheter (PAC) use in heart failure admissions. Little is known about the national trends in other previously common indications for PAC placement, PAC use overall, or outcomes associated with PAC placement.

OBJECTIVE

To determine national trends in PAC use overall as well as across sociodemographic groups and key clinical conditions, including acute myocardial infarction, heart failure, and respiratory failure.

DESIGN, SETTING, AND PARTICIPANTS: Centers for Medicare and Medicaid Services inpatient claims data and International Classification of Diseases, Ninth Revision, Clinical Modification codes were used to conduct a serial cross-sectional cohort study between January 1, 1999, and December 31, 2013, identifying hospitalizations during which a PAC was placed. Data analysis was conducted from September 25, 2015, to April 10, 2017.

MAIN OUTCOMES AND MEASURES

Rate of use of a PAC per 1000 admissions, 30-day mortality, and length of stay.

RESULTS

Among the 68 374 904 unique Medicare beneficiaries in the study, there were 469 582 hospitalizations among 457 193 patients (204 232 women and 252 961 men; mean [SD] age, 76.3 [6.9] years) during which a PAC was placed. There was a 67.8% relative decrease in PAC use (6.28 per 1000 admissions in 1999 to 2.02 per 1000 admissions in 2013; P < .001), with 2 distinct trends: significant year-on-year decreases from 1999 to 2011, followed by stable use through 2013. There was variation in rates of PAC use across race/ethnicity, age, and sex, but use decreased across all subgroups. Although there were sustained decreases in PAC use for acute myocardial infarction (20.0 PACs placed per 1000 admissions in 1999 to 5.2 in 2013 [74.0% reduction]; P < .001 for trend) and respiratory failure (29.9 PACs placed per 1000 admission in 1999 to 2.3 in 2013 [92.3% reduction]; P < .001 for trend) during the study period, there was an initial decrease in PAC use in heart failure, with a nadir in 2009 followed by a subsequent increase (9.1 PACs placed per 1000 admissions in 1999 to 4.0 in 2009 to 5.8 in 2013). In-hospital mortality, 30-day mortality, and length of stay decreased during the study period.

CONCLUSIONS AND RELEVANCE

In the wake of mounting evidence suggesting a lack of benefit to the routine use of PACs, there has been a de-adoption of PAC use overall and across sociodemographic groups but heterogeneity in patterns of use across clinical conditions. The clinical outcomes of patients with PACs have significantly improved. These findings raise important questions about the optimal use of PACs and the drivers of the observed trends.

摘要

重要性

最近的研究观察到心力衰竭入院患者肺动脉导管(PAC)使用率的增加。对于其他先前常见的 PAC 放置适应证、PAC 的总体使用情况或与 PAC 放置相关的结果,知之甚少。

目的

确定 PAC 总体使用情况以及在社会人口统计学群体和关键临床情况下的全国趋势,包括急性心肌梗死、心力衰竭和呼吸衰竭。

设计、设置和参与者:利用医疗保险和医疗补助服务中心的住院患者数据和国际疾病分类,第九修订版,临床修正码进行了一项连续的横断面队列研究,研究时间为 1999 年 1 月 1 日至 2013 年 12 月 31 日,确定了 PAC 放置的住院情况。数据分析于 2015 年 9 月 25 日至 2017 年 4 月 10 日进行。

主要结果和措施

每 1000 例入院患者 PAC 使用的比率、30 天死亡率和住院时间。

结果

在研究中,68374904 名独特的医疗保险受益人群中,有 457193 名患者(204232 名女性和 252961 名男性;平均[SD]年龄,76.3[6.9]岁)的 469582 例住院期间放置了 PAC。PAC 使用量相对减少了 67.8%(1999 年为每 1000 例住院 6.28 例,2013 年为每 1000 例住院 2.02 例;P < .001),存在 2 个明显趋势:1999 年至 2011 年逐年下降,随后至 2013 年稳定使用。在种族/族裔、年龄和性别方面,PAC 使用率存在差异,但所有亚组的使用量均有所下降。尽管在急性心肌梗死(1999 年每 1000 例住院 20.0 例 PAC,2013 年每 1000 例住院 5.2 例[74.0%减少];趋势 P < .001)和呼吸衰竭(1999 年每 1000 例住院 29.9 例 PAC,2013 年每 1000 例住院 2.3 例[92.3%减少];趋势 P < .001)期间,PAC 的使用率持续下降,但心力衰竭患者的 PAC 使用量最初下降,2009 年达到最低点,随后再次上升(1999 年每 1000 例住院 9.1 例 PAC,2009 年每 1000 例住院 4.0 例,2013 年每 1000 例住院 5.8 例)。研究期间,院内死亡率、30 天死亡率和住院时间均有所下降。

结论和相关性

在越来越多的证据表明常规使用 PAC 没有益处之后,PAC 的总体使用情况以及在社会人口统计学群体中都有所减少,但在临床情况下的使用模式存在异质性。PAC 患者的临床结果显著改善。这些发现提出了有关 PAC 最佳使用和观察到的趋势驱动因素的重要问题。

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