母亲服用羟氯喹后，未发现胎儿心脏毒性的组织学证据。
No histologic evidence of foetal cardiotoxicity following exposure to maternal hydroxychloroquine.
作者信息
Friedman Deborah, Lovig Leif, Halushka Marc, Clancy Robert M, Izmirly Peter M, Buyon Jill P
机构信息
Paediatric Cardiology, New York Medical College, USA.
Paediatric Cardiology, Children's and Women's Physicians of Westchester LLP, Norwalk, CT, USA.
出版信息
Clin Exp Rheumatol. 2017 Sep-Oct;35(5):857-859. Epub 2017 Jun 6.
Abstract
It is currently recommended that hydroxychloroquine (HCQ) be maintained during pregnancy in patients with systemic lupus erythematosus. Recent data suggest that this Toll-like receptor inhibitor may also reduce the recurrence rate of anti-SSA/Ro associated congenital heart block (CHB). This case report describes a unique situation in which a CHB-afflicted, HCQ-exposed pregnancy was electively terminated. The heart did not reveal any characteristic features of cardiotoxicity, providing further evidence supporting the safety of foetal exposure to HCQ.
摘要
目前建议，系统性红斑狼疮患者在孕期应持续使用羟氯喹（HCQ）。近期数据表明，这种Toll样受体抑制剂或许还能降低抗SSA/Ro相关先天性心脏传导阻滞（CHB）的复发率。本病例报告描述了一种特殊情况，即一名患有CHB且接触过HCQ的孕妇选择终止妊娠。心脏未显示出任何心脏毒性的特征，这进一步证明了胎儿接触HCQ的安全性。
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