Lagarda-Diaz Irlanda, Guzman-Partida Ana Maria, Vazquez-Moreno Luz
CONACyT-Universidad de Sonora, Blvd. Luis Encinas y Rosales, Hermosillo, Sonora 83000, Mexico.
Coordinacion de Ciencia de los Alimentos, Centro de Investigacion en Alimentacion y Desarrollo, A.C., Apartado Postal 1735, Hermosillo, Sonora 83304, Mexico.
Int J Mol Sci. 2017 Jun 12;18(6):1242. doi: 10.3390/ijms18061242.
Lectins are a diverse class of proteins distributed extensively in nature. Among these proteins; legume lectins display a variety of interesting features including antimicrobial; insecticidal and antitumor activities. Because lectins recognize and bind to specific glycoconjugates present on the surface of cells and intracellular structures; they can serve as potential target molecules for developing practical applications in the fields of food; agriculture; health and pharmaceutical research. This review presents the current knowledge of the main structural characteristics of legume lectins and the relationship of structure to the exhibited specificities; provides an overview of their particular antimicrobial; insecticidal and antitumor biological activities and describes possible applications based on the pattern of recognized glyco-targets.
凝集素是一类广泛分布于自然界的多样蛋白质。在这些蛋白质中,豆类凝集素展现出多种有趣的特性,包括抗菌、杀虫和抗肿瘤活性。由于凝集素能够识别并结合细胞表面和细胞内结构上存在的特定糖缀合物,它们可作为在食品、农业、健康和药物研究领域开发实际应用的潜在靶分子。本综述介绍了豆类凝集素主要结构特征的当前知识以及结构与所表现出的特异性之间的关系,概述了它们特殊的抗菌、杀虫和抗肿瘤生物活性,并基于所识别的糖靶模式描述了可能的应用。