髓鞘少突胶质细胞糖蛋白在针对中枢神经系统髓鞘的T细胞自身免疫中具有双重作用。
Myelin oligodendrocyte glycoprotein has a dual role in T cell autoimmunity against central nervous system myelin.
作者信息
't Hart Bert A, Weissert Robert
机构信息
Department of Immunobiology, Biomedical Primate Research Centre, The Netherlands.
Department of Neurology, University of Regensburg, Germany.
出版信息
Mult Scler J Exp Transl Clin. 2016 Feb 7;2:2055217316630999. doi: 10.1177/2055217316630999. eCollection 2016 Jan-Dec.
BACKGROUND
Myelin oligodendrocyte glycoprotein (MOG) is a candidate primary target of the autoimmune attack on the central nervous system (CNS) in multiple sclerosis (MS). However, the physiological function of MOG has been unclear for a long time.
OBJECTIVE
We propose that MOG has a central role in the regulation of tolerance and autoimmunity.
CONCLUSION
The interaction of MOG with DC-SIGN, an innate antigen receptor of myeloid antigen-presenting cells (m-APCs), present inside the CNS (microglia) or in draining lymph nodes (dendritic cells; DCs), keeps these cells in an immature/tolerogenic state. We postulate that this tolerogenic mechanism may be disturbed in MS by unknown factors.
背景
髓鞘少突胶质细胞糖蛋白（MOG）是多发性硬化症（MS）中自身免疫攻击中枢神经系统（CNS）的主要候选靶点。然而，长期以来MOG的生理功能尚不清楚。
目的
我们提出MOG在耐受性和自身免疫调节中起核心作用。
结论
MOG与DC-SIGN相互作用，DC-SIGN是髓样抗原呈递细胞（m-APC）的一种天然抗原受体，存在于CNS内（小胶质细胞）或引流淋巴结（树突状细胞；DC）中，使这些细胞保持未成熟/耐受性状态。我们推测，这种耐受性机制在MS中可能会受到未知因素的干扰。
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