Han Jinu, Lee Taekjune, Lee Jong Bok, Han Sueng-Han
Institute of Vision Research, Department of Ophthalmology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Institute of Vision Research, Department of Ophthalmology, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seoul, Seodaemun-gu, 03572, Korea.
Graefes Arch Clin Exp Ophthalmol. 2017 Aug;255(8):1661-1668. doi: 10.1007/s00417-017-3713-y. Epub 2017 Jun 14.
To compare segmented retinal layer thicknesses between patients with idiopathic infantile nystagmus (IIN) and controls.
This retrospective case-control study included 66 patients with IIN and 66 age-matched controls. The retinal layers were examined using spectral domain optical coherence tomography with autosegmentation. Central foveal thickness (CFT), outer nuclear layer (ONL), and outer segment length (OSL) thickness were measured at the fovea center. Mean values for retinal nerve fiber layer, ganglion cell inner plexiform layer (GCIPL), inner nuclear layer, outer plexiform-outer nuclear layer (OPNL) thicknesses were calculated at two measurement points (nasal and temporal hump points at the macula area).
There were no significant between-group differences in age, gender, or refraction error. The CFT was thicker in the IIN group compared with the control group (225.0 μm vs. 217.8 μm, P = 0.017) and OSL was shorter in IIN than in controls (40.0 μm vs. 43.7 μm., P < 0.001). The ONL thickness at the central fovea was not statistically different between the two groups. At the nasal and temporal position where the ganglion cell density was thickest, the GCIPL thickness was thinner in the IIN group compared to the controls (99.5 μm vs. 102.8 μm, P = 0.010). The GCIPL thickness was negatively correlated with logMAR visual acuity (Spearman's rho = -0.502, P < 0.001).
The foveal pit was shallower, OSL was shorter, and the GCIPL thicknesses at macular humps were decreased in the patients with IIN compared with that of controls. The faulty development of the macula may be related to unknown pathophysiologic mechanism during fovea maturation in IIN or continuous eye movement itself interrupt fovea development.
比较特发性婴儿型眼球震颤（IIN）患者与对照组的视网膜各层厚度。
这项回顾性病例对照研究纳入了66例IIN患者和66例年龄匹配的对照组。使用具有自动分割功能的光谱域光学相干断层扫描检查视网膜各层。在黄斑中心测量中心凹厚度（CFT）、外核层（ONL）和外段长度（OSL）厚度。在两个测量点（黄斑区鼻侧和颞侧隆起点）计算视网膜神经纤维层、神经节细胞内丛状层（GCIPL）、内核层、外丛状 - 外核层（OPNL）厚度的平均值。
两组在年龄、性别或屈光不正方面无显著组间差异。IIN组的CFT比对照组厚（225.0μm对217.8μm，P = 0.017），IIN组的OSL比对照组短（40.0μm对43.7μm，P < 0.001）。两组中央凹处的ONL厚度无统计学差异。在神经节细胞密度最高的鼻侧和颞侧位置，IIN组的GCIPL厚度比对照组薄（99.5μm对102.8μm，P = 0.010）。GCIPL厚度与logMAR视力呈负相关（Spearman相关系数ρ = -0.502，P < 0.001）。
与对照组相比，IIN患者的黄斑凹陷更浅，OSL更短，黄斑隆起处的GCIPL厚度降低。黄斑发育异常可能与IIN患者黄斑成熟过程中未知的病理生理机制有关，或者持续的眼球运动本身干扰了黄斑发育。
