自由基促进的铜催化 α,β-不饱和羧酸与 ICHCF 及其类似物的脱羧烷基化反应。
Free-Radical-Promoted Copper-Catalyzed Decarboxylative Alkylation of α,β-Unsaturated Carboxylic Acids with ICHCF and Its Analogues.
机构信息
School of Pharmacy, Fudan University , 826 Zhangheng Road, Pudong, Shanghai 201203, China.
出版信息
J Org Chem. 2017 Jul 21;82(14):7428-7436. doi: 10.1021/acs.joc.7b01107. Epub 2017 Jun 30.
PMID:28636380
Abstract
A novel and efficient free-radical-promoted copper-catalyzed decarboxylative alkylation of α,β-unsaturated carboxylic acids with ICHCF and its analogues has been developed. This methodology provides a convenient access to the synthesis of allylic trifluoromethyl and β-CF ketone containing compounds as well as other biologically useful fluorinated molecules and materials.
摘要
一种新颖高效的自由基促进的铜催化脱羧烷基化反应已经被开发出来，用于α,β-不饱和羧酸与 ICHCF 及其类似物的反应。这种方法为合成烯丙基三氟甲基和β-CF 酮类化合物以及其他具有生物应用价值的氟化分子和材料提供了一种便捷的途径。
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