99mTc-HMPAO在精神分裂症谱系障碍暴力患者诊断流程中的应用经验。
Experiences with 99mTc-HMPAO in a Diagnostic Pathway for Violent Patients with Schizophrenic Spectrum Disorders.
作者信息
Jacobsen Morten, Jensen Arvid, Storvestre Guttorm Breivik, Bergstrom Tone Marie, Mohamad Rashi Diyar Nori, Nielssen Bjorn, Wiktor Pal, Hymer Knut-Erik
机构信息
University of Oslo, Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Postbox 1171 Blindern 0318, Oslo. Norway.
Sykehuset Ostfold, Department of Psychiatry, Postbox 300, 1714 Grålum. Norway.
出版信息
Curr Radiopharm. 2017 Aug 24;10(2):115-122. doi: 10.2174/1874471010666170621122221.
BACKGROUND AND OBJECTIVE
In a security ward we assessed the diagnostic contribution of single photon scintigraphy [SPECT] in our diagnostic pathway for patients with serious mental disease and a history of violence.
METHODS
Twenty patients were examined between 2012 and 2015 and the findings compared to those in nine patients with the same diagnosis, but no history of violence.
RESULTS
All violent patients had areas with reduced accumulation of 99mTc-HMPAO frontally and in the temporal lobe, in the non-violent group only two patients demonstrated these findings.
CONCLUSION
Traditionally, low accumulation of the tracer in SPECT is related to reduced perfusion of brain tissue. We discuss our findings in the light of other possible pathophysiological mechanisms.
背景与目的
在一个安全病房中，我们评估了单光子闪烁扫描术（SPECT）在患有严重精神疾病且有暴力史患者的诊断流程中的诊断贡献。
方法
2012年至2015年间对20名患者进行了检查，并将结果与9名诊断相同但无暴力史的患者的结果进行比较。
结果
所有有暴力行为的患者额叶和颞叶均有99mTc - HMPAO聚集减少的区域，在无暴力行为的组中只有两名患者有这些表现。
结论
传统上，SPECT中示踪剂的低聚集与脑组织灌注减少有关。我们根据其他可能的病理生理机制讨论了我们的发现。
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