Lgr5 加入胃底干细胞标志物俱乐部。
Lgr5 joins the club of gastric stem cell markers in the corpus.
机构信息
European Cancer Stem Cell Research Institute, Cardiff University, Cardiff CF24 4HQ, UK.
Cancer Research UK Beatson Institute, Garscube Estate, Bearsden, Glasgow G61 1BD, UK and at the Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1BD, UK.
出版信息
Nat Cell Biol. 2017 Jun 29;19(7):752-754. doi: 10.1038/ncb3567.
DOI:10.1038/ncb3567
PMID:28659641
Abstract
Several markers of gastric stem cells have been identified in recent years. Now a study demonstrates that Lgr5 marks a population of reserve stem cells located at the base of the corpus glands of the gastric epithelium, and that these cells can also act as a cell-of-origin for gastric tumorigenesis.
摘要
近年来，已经鉴定出了几种胃干细胞标志物。现在的一项研究表明，Lgr5 标记了胃上皮体腺底部的储备干细胞群体，这些细胞也可以作为胃肿瘤发生的起始细胞。
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