Comparative efficacy of herbal essences with amphotricin B and ketoconazole on in the condition.

BACKGROUND

The species are the most important factors of fungal infections in humans and animals. It is necessary to prepare antifungal or antimicrobial drugs because of increasing drug resistance. The natural treatment of diseases of bacterial origin using medicinal plants is important. In this study the effect of antimicrobial medicinal herbal essential oils and conventional antifungal drugs were evaluated on .

METHODS

Disc diffusion assay and the microbroth dilution method were used to investigate the anticandidal effects of Mill, L, , and Boiss essential oils. The anticandidal effect of these essential oils was compared with that of amphotricin B and ketoconazole We then measured the chemical composition of the studied essential oils using gas chromatography-mass spectroscopy.

RESULTS

Boiss essential oil at the minimum inhibitory concentration (MIC) of 34 μg/mL and minimal lethal concentration [i.e., minimal fungicidal concentration (MFC)] of 64 μg/mL had more powerful anti- activity than the other essential oils. essential oil showed the least effect on the tested fungus. A comparison of the effect of the studied essential oils and antifungal drugs showed that the antifungal effect on the fungus was better with the fungicides than with the essential oils.

CONCLUSION

In the present study, essential oils with different components showed antifungal activity (especially Boiss essential oil). They can therefore be used as new antifungal substances.