粒细胞作为卡介苗治疗膀胱癌的一种效应机制。

Granulocytes as an effector mechanism of BCG therapy for bladder cancer.

作者信息

Davis Ronald L, Le Wenjun, Cui Zheng

机构信息

Department of Urology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.

Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA; The Institute for Translational Nanomedicine, Shanghai East Hospital, The Institute for Biomedical Engineering & Nano Science, Tongji University School of Medicine, Shanghai 200120, China.

出版信息

Med Hypotheses. 2017 Jul;104:166-169. doi: 10.1016/j.mehy.2017.05.011. Epub 2017 May 10.

DOI:10.1016/j.mehy.2017.05.011

PMID:28673578

Abstract

The overall efficacy of BCG therapy is remarkably high but the mechanism of its action is still elusive. The success of BCG therapy depends on several factors that may give clues to its effector mechanism: a competent immune system, a sufficient number of live BCG, a development of fever and the death of cancer cells. Here we propose a theory for the action mechanism of the BCG therapy for the bladder cancer treatment by establishing the logical connection of these required elements. The center concept of the BCG therapy mechanism is to activate granulocytes that in turn kill bladder cancer cells directly by its major effector mechanism: degranulation.

摘要

卡介苗疗法的总体疗效非常高，但其作用机制仍不清楚。卡介苗疗法的成功取决于几个因素，这些因素可能为其效应机制提供线索：一个有功能的免疫系统、足够数量的活卡介苗、发热的出现以及癌细胞的死亡。在这里，我们通过建立这些必需元素之间的逻辑联系，提出了一种关于卡介苗治疗膀胱癌作用机制的理论。卡介苗治疗机制的核心概念是激活粒细胞，粒细胞继而通过其主要效应机制：脱颗粒，直接杀死膀胱癌细胞。