Schelling J L
Schweiz Med Wochenschr. 1985 Dec 14;115(50):1808-14.
The response to narcotics, sedatives, hypnotics, antidepressants and antipsychotic drugs is modified in elderly patients. The effects of these drugs are enhanced, and dosage reduction is required. This phenomenon is gradual and occurs before any sign of senile dementia. The choice of a drug within a therapeutic class may depend on the severity of adverse reactions, some of which are particularly disturbing in elderly patients.
老年患者对麻醉药、镇静剂、催眠药、抗抑郁药和抗精神病药物的反应会发生改变。这些药物的作用会增强,需要减少剂量。这种现象是渐进的,且在出现任何老年痴呆迹象之前就会发生。在治疗类别中选择药物可能取决于不良反应的严重程度,其中一些不良反应对老年患者尤其困扰。