一种由截短的原肌球蛋白和蛋白酪氨酸激酶序列融合形成的人类癌基因。
A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences.
作者信息
Martin-Zanca D, Hughes S H, Barbacid M
出版信息
Nature. 1986;319(6056):743-8. doi: 10.1038/319743a0.
DOI:10.1038/319743a0
PMID:2869410
Abstract
A biologically active complementary DNA clone of a transforming gene present in a human colon carcinoma contains gene sequences of both tropomyosin and a previously unknown protein tyrosine kinase. The predicted protein (641 amino acids) encoded by this oncogene seems to have been formed by a somatic rearrangement that replaced the extracellular domain of a putative transmembrane receptor by the first 221 amino acids of a non-muscle tropomyosin molecule.
摘要
一个存在于人类结肠癌中的转化基因的具有生物活性的互补DNA克隆，包含原肌球蛋白和一种此前未知的蛋白酪氨酸激酶的基因序列。由这个癌基因编码的预测蛋白（641个氨基酸）似乎是通过体细胞重排形成的，这种重排用非肌肉原肌球蛋白分子的前221个氨基酸取代了一个假定跨膜受体的细胞外结构域。
Zotero 插件