Lemos Thaisa, Gallagher Dympna
aDepartment of Medicine, New York Obesity Nutrition Research Center, Columbia University Medical Center bDepartment of Medicine, New York Obesity Nutrition Research Center, Columbia University, New York, New York, USA.
Curr Opin Endocrinol Diabetes Obes. 2017 Oct;24(5):310-314. doi: 10.1097/MED.0000000000000360.
The current article reviews the most innovative and precise, available methods for quantification of in-vivo human body composition.
Body composition measurement methods are continuously being perfected. Ongoing efforts involve multisegmental and multifrequency bioelectrical impedance analysis, quantitative magnetic resonance for total body water, fat, and lean tissue measurements, imaging to further define ectopic fat depots. Available techniques allow for the measurement of fat, fat-free mass, bone mineral content, total body water, extracellular water, total adipose tissue and its subdepots (visceral, subcutaneous, and intermuscular), skeletal muscle, select organs, and ectopic fat depots.
There is an ongoing need for methods that yield information on metabolic and biological functions. Based on the wide range of measurable properties, analytical methods and known body composition models, clinicians, and scientists can quantify a number of body components and with longitudinal assessment, can track changes in health and disease with implications for understanding efficacy of nutritional and clinical interventions, diagnosis, prevention, and treatment in clinical settings. With the greater need to understand precursors of health risk beginning prior to conception, a gap exists in appropriate in-vivo measurement methods with application beginning during gestation, that is, fetal development.
本文综述了目前用于定量活体人体成分的最具创新性和精确性的可用方法。
人体成分测量方法在不断完善。正在进行的工作包括多节段和多频率生物电阻抗分析、用于测量全身水、脂肪和瘦组织的定量磁共振成像、用于进一步明确异位脂肪储存部位的成像技术。现有技术可用于测量脂肪、去脂体重、骨矿物质含量、全身水、细胞外液、总脂肪组织及其亚储存部位(内脏、皮下和肌间)、骨骼肌、特定器官和异位脂肪储存部位。
目前持续需要能够提供有关代谢和生物学功能信息的方法。基于广泛的可测量特性、分析方法和已知的人体成分模型,临床医生和科学家可以对多种身体成分进行定量,并且通过纵向评估,可以跟踪健康和疾病的变化,这对于理解营养和临床干预措施的疗效、诊断、预防以及临床环境中的治疗具有重要意义。鉴于在受孕前就需要更好地了解健康风险的先兆,在孕期即胎儿发育期间开始应用的合适的活体测量方法方面存在差距。