Chan Warren Ho, Sugarbaker David J, Burt Bryan M
Division of Thoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA.
Transl Lung Cancer Res. 2017 Jun;6(3):285-294. doi: 10.21037/tlcr.2017.05.04.
Malignant pleural mesothelioma (MPM) is a rapidly fatal disease. Multimodality surgically based therapies may extend survival in select patients, however, local relapse after resection is common. Novel intraoperative adjunctive therapies including heated intraoperative chemotherapy (HIOC), heated intraoperative povidone-iodine (PVP-I), and photodynamic therapy (PDT) target micrometastatic disease and aim to improve local control. This review details the most recent studies and trials of HIOC, heated intraoperative PVP-I, and PDT, this aims to provide an update on some of the most promising intraoperative adjuncts for patients with MPM.
恶性胸膜间皮瘤(MPM)是一种进展迅速的致命疾病。多模式手术治疗可能会延长部分患者的生存期,然而,切除术后局部复发很常见。新型术中辅助治疗,包括术中热化疗(HIOC)、术中热聚维酮碘(PVP-I)和光动力疗法(PDT),针对微转移病灶,旨在改善局部控制。本综述详细介绍了HIOC、术中热PVP-I和PDT的最新研究与试验,旨在为MPM患者提供一些最有前景的术中辅助治疗的最新情况。