Sanz Ivan, Rojo Silvia, Tamames Sonia, Eiros José María, Ortiz de Lejarazu Raúl
Valladolid National Influenza Centre, Avenida Ramón y Cajal s/n, 47005 Valladolid, Spain.
Microbiology Service, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal s/n, 47005 Valladolid, Spain.
Vaccines (Basel). 2017 Jul 17;5(3):17. doi: 10.3390/vaccines5030017.
Avian influenza viruses are currently one of the main threats to human health in the world. Although there are some screening reports of antibodies against these viruses in humans from Western countries, most of these types of studies are conducted in poultry and market workers of Asian populations. The presence of antibodies against avian influenza viruses was evaluated in an elderly European population. An experimental study was conducted, including pre- and post-vaccine serum samples obtained from 174 elderly people vaccinated with seasonal influenza vaccines of 2006-2007, 2008-2009, 2009-2010, and 2010-2011 Northern Hemisphere vaccine campaigns. The presence of antibodies against A/H5N1, A/H7N3, and A/H9N2 avian influenza viruses were tested by using haemaglutination inhibition assays. Globally, heterotypic antibodies were found before vaccination in 2.9% of individuals against A/H5N1, 1.2% against A/H7N3, and 25.9% against A/H9N2. These pre-vaccination antibodies were present at titers ≥1/40 in 1.1% of individuals against A/H5N1, in 1.1% against H7N3, and in 0.6% against the A/H9N2 subtype. One 76 year-old male showed pre-vaccine antibodies (Abs) against those three avian influenza viruses, and another three individuals presented Abs against two different viruses. Seasonal influenza vaccination induced a significant number of heterotypic seroconversions against A/H5N1 (14.4%) and A/H9N2 (10.9%) viruses, but only one seroconversion was observed against the A/H7N3 subtype. After vaccination, four individuals showed Abs titers ≥1/40 against those three avian viruses, and 55 individuals against both A/H5N1 and A/H9N2. Seasonal vaccination is able to induce some weak heterotypic responses to viruses of avian origin in elderly individuals with no previous exposure to them. However, this response did not accomplish the European Medicament Agency criteria for influenza vaccine efficacy. The results of this study show that seasonal vaccines induce a broad response of heterotypic antibodies against avian influenza viruses, albeit at a low level.
禽流感病毒是目前全球人类健康面临的主要威胁之一。尽管西方国家有一些关于人类体内针对这些病毒抗体的筛查报告，但这类研究大多是在亚洲人群的家禽和市场工作人员中进行的。本研究评估了欧洲老年人群中针对禽流感病毒抗体的存在情况。开展了一项实验研究，纳入了从2006 - 2007年、2008 - 2009年、2009 - 2010年以及2010 - 2011年北半球流感疫苗接种活动中接种季节性流感疫苗的174名老年人的疫苗接种前和接种后血清样本。通过血凝抑制试验检测针对A/H5N1、A/H7N3和A/H9N2禽流感病毒抗体的存在情况。在全球范围内，接种疫苗前，2.9%的个体存在针对A/H5N1的异型抗体，1.2%针对A/H7N3，25.9%针对A/H9N2。这些接种疫苗前的抗体在1.1%的个体中针对A/H5N1、1.1%针对H7N3、0.6%针对A/H9N2亚型的滴度≥1/40。一名76岁男性在接种疫苗前显示出针对这三种禽流感病毒的抗体，另外三名个体显示出针对两种不同病毒的抗体。季节性流感疫苗接种诱导了大量针对A/H5N1（14.4%）和A/H9N2（10.9%）病毒的异型血清转化，但仅观察到1例针对A/H7N3亚型的血清转化。接种疫苗后，4名个体显示针对这三种禽流感病毒的抗体滴度≥1/40，55名个体针对A/H5N1和A/H9N2两种病毒。季节性疫苗接种能够在以前未接触过禽流感病毒的老年个体中诱导一些针对禽源病毒的微弱异型反应。然而，这种反应未达到欧洲药品管理局关于流感疫苗效力的标准。本研究结果表明，季节性疫苗能诱导针对禽流感病毒的广泛异型抗体反应，尽管水平较低。
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