原子力显微镜研究 DNA-蛋白质相互作用。

DNA-protein interactions explored by atomic force microscopy.

机构信息

Laboratoire de Physique de la Matière Vivante, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland; Plateforme de Morphologie, Faculté de Médecine, Université de Lausanne, Bugnion 9, 1005 Lausanne, Switzerland.

Laboratoire de Physique de la Matière Vivante, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

出版信息

Semin Cell Dev Biol. 2018 Jan;73:231-239. doi: 10.1016/j.semcdb.2017.07.015. Epub 2017 Jul 14.

DOI:10.1016/j.semcdb.2017.07.015

PMID:28716606

Abstract

DNA-protein interactions play an important role in all living organisms on Earth. The advent of atomic force microscopy permitted for the first time to follow and to characterize interaction forces between these two molecular species. After a short description of the AFM and its imaging modes we review, in a chronological order some of the studies that we think importantly contributed to the field.

摘要

DNA-蛋白质相互作用在地球上所有生物中都起着重要作用。原子力显微镜的出现首次允许我们跟踪和描述这两种分子之间的相互作用力。在简要描述原子力显微镜及其成像模式之后，我们按时间顺序回顾了一些我们认为对该领域有重要贡献的研究。