人体血管中的α-肾上腺素能受体。
Alpha-adrenergic receptors in human blood vessels.
作者信息
van Brummelen P, Jie K, van Zwieten P A
出版信息
Br J Clin Pharmacol. 1986;21 Suppl 1(Suppl 1):33S-39S. doi: 10.1111/j.1365-2125.1986.tb02851.x.
Abstract
The evidence for the presence of postjunctional alpha 1- and alpha 2-adrenoceptor subtypes in human blood vessels is reviewed. Experiments in healthy subjects are described that show that alpha 1- as well as alpha 2-adrenoceptor mediated vasoconstriction contribute to vascular smooth muscle tone and that adrenaline and noradrenaline have similar affinities for each subtype. In addition, evidence is presented for a preferential intrajunctional location of alpha 1-adrenoceptors and a preferential extrajunctional location of alpha 2-adrenoceptors in human blood vessels. It is concluded that at present postjunctional alpha-adrenoceptors in human blood vessels can be classified as alpha 1 and alpha 2. Despite the fact that both subtypes mediate vasoconstriction, these receptors are likely to subserve different physiological functions.
摘要
本文综述了人类血管中存在节后α1和α2肾上腺素能受体亚型的证据。文中描述了在健康受试者身上进行的实验，这些实验表明α1以及α2肾上腺素能受体介导的血管收缩均有助于维持血管平滑肌张力，且肾上腺素和去甲肾上腺素对每种亚型具有相似的亲和力。此外，有证据表明人类血管中α1肾上腺素能受体优先位于接头内，而α2肾上腺素能受体优先位于接头外。得出的结论是，目前人类血管中的节后α肾上腺素能受体可分为α1和α2。尽管这两种亚型均介导血管收缩，但这些受体可能具有不同的生理功能。
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