de Vos Willem M
Research Programme Unit Immunobiology, Department of Bacteriology and Immunology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland.
NPJ Biofilms Microbiomes. 2015 Mar 25;1:15005. doi: 10.1038/npjbiofilms.2015.5. eCollection 2015.
Since early life we are colonised by a myriad of microbes that make up our microbiome. This colonisation process starts at birth or even before, when the virtually sterile baby encounters new microbial environments. It is likely that at this time or at later moments in life, microbial communities are met that have high-level structures with a temporal and spatial organisation, termed biofilms. This perspective will focus on these biofilms and the microbes in the intestinal tract as these are the most numerous in the human body, are found in luminal and mucosal locations, and have a great impact on human health and disease.
从生命早期开始，我们就被无数构成我们微生物群的微生物所定植。这种定植过程在出生时甚至更早开始，此时几乎无菌的婴儿会接触到新的微生物环境。很可能在这个时候或在生命的后期，会遇到具有时间和空间组织的高级结构的微生物群落，即生物膜。本文将重点关注这些生物膜以及肠道中的微生物，因为它们在人体中数量最多，存在于管腔和黏膜部位，并且对人类健康和疾病有重大影响。
