姜黄的化学成分及其对一氧化氮生成的抑制作用。
Chemical constituents from Curcuma longa L. and their inhibitory effects of nitric oxide production.
作者信息
Yuan Ting, Zhang Cuiyun, Qiu Chongyue, Xia Guiyang, Wang Fei, Lin Bin, Li Hua, Chen Lixia
机构信息
a Key Laboratory of Structure-Based Drug Design & Discovery, School of Traditional Chinese Materia Medica, Ministry of Education , Wuya College of Innovation, Shenyang Pharmaceutical University , Shenyang , People's Republic of China.
b Key Laboratory of Structure-Based Drug Design & Discovery, School of Pharmaceutical Engineering , Ministry of Education, Shenyang Pharmaceutical University , Shenyang , People's Republic of China.
出版信息
Nat Prod Res. 2018 Aug;32(16):1887-1892. doi: 10.1080/14786419.2017.1354185. Epub 2017 Jul 20.
A new bisabolane-type sesquiterpenoid, turmerone Q (1), along with six known compounds (2-7), were isolated from the rhizomes of Curcuma longa L. The structural elucidation of the new compound was conducted using H NMR, C NMR, HSQC, HMBC and NOESY spectroscopic analyses. The absolute configuration of 1 was elucidated by comparison of the experimental and calculated ECD spectra. The anti-inflammatory effects of 1-7 were evaluated through lipopolysaccharide-induced nitric oxide (NO) production in RAW 264.7 macrophages assays, and compounds 6 and 7 showed potent inhibitory activity against NO production.
从姜黄的根茎中分离出一种新的没药烷型倍半萜类化合物——姜黄酮Q（1），以及六种已知化合物（2 - 7）。通过¹H NMR、¹³C NMR、HSQC、HMBC和NOESY光谱分析对新化合物进行结构解析。通过比较实验和计算的ECD光谱确定了1的绝对构型。通过脂多糖诱导RAW 264.7巨噬细胞产生一氧化氮（NO）的实验评估了1 - 7的抗炎作用，化合物6和7对NO的产生显示出强效抑制活性。
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