代谢酶在免疫和转移中的核定位。
Nuclear localization of metabolic enzymes in immunity and metastasis.
机构信息
Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, China; Cancer Research Institute, School of Basic Medicine, Central South University, 110 Xiangya Road, Changsha, Hunan 410078, China; Department of Thoracic Surgery, Second Xiangya Hospital, Central South University, Changsha, China.
Institute of Medical Sciences, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, China.
出版信息
Biochim Biophys Acta Rev Cancer. 2017 Dec;1868(2):359-371. doi: 10.1016/j.bbcan.2017.07.002. Epub 2017 Jul 27.
Metabolism is essential to all living organisms that provide cells with energy, regulators, building blocks, enzyme cofactors and signaling molecules, and is in tune with nutritional conditions and the function of cells to make the appropriate developmental decisions or maintain homeostasis. As a fundamental biological process, metabolism state affects the production of multiple metabolites and the activation of various enzymes that participate in regulating gene expression, cell apoptosis, cancer progression and immunoreactions. Previous studies generally focus on the function played by the metabolic enzymes in the cytoplasm and mitochondrion. In this review, we conclude the role of them in the nucleus and their implications for cancer progression, immunity and metastasis.
新陈代谢对于为细胞提供能量、调节剂、构建块、酶辅因子和信号分子的所有生物体都是必不可少的，它与营养状况和细胞功能相协调，以做出适当的发育决策或维持体内平衡。作为一个基本的生物过程，代谢状态会影响多种代谢物的产生以及参与调节基因表达、细胞凋亡、癌症进展和免疫反应的各种酶的激活。以前的研究通常集中在细胞质和线粒体中代谢酶的作用上。在这篇综述中，我们总结了它们在核内的作用及其对癌症进展、免疫和转移的影响。
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