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厚脉络膜疾病谱。

Spectrum of pachychoroid diseases.

作者信息

Akkaya Sezen

机构信息

Ophthalmology Department, Fatih Sultan Mehmet Training and Research Hospital, E-5 Üzeri, Üst Bostanci, Istanbul, Turkey.

, Salacak Mah. Fıstıklı Namazgah Sok. Konakkaya. No: 3, Üsküdar, Istanbul, Turkey.

出版信息

Int Ophthalmol. 2018 Oct;38(5):2239-2246. doi: 10.1007/s10792-017-0666-4. Epub 2017 Aug 1.

Abstract

PURPOSE

To perform a systematic review of the literature examining about the pachychoroid diseases spectrum.

METHODS

A systematic literature search was performed using the Medline database. A total of four studies directly relevant to our search are reviewed here.

RESULTS

A structurally and functionally intact choroid tissue is vitally important for the retina function. While central retinal artery is responsible to supply the 2/3, internal part of the retina, choroidal vein network is responsible for the remaining 1/3 external part. Abnormal choroidal blood flow leads to photoreceptor dysfunction and photoreceptor death in the retina. The methods used in the visualization of the choroid are ICG angiography (indocyanine green angiography), OCT (optic coherence tomography) devices which are often used nowadays, and its advanced version, OCT angiography. Pachychoroid diseases are a spectrum of 4 different disease groups. These groups are essentially the stages of the disease itself, as the increased severity in the previous group leads the patient to the next group of disease.

CONCLUSION

The spectrum comprises the following 4 disease groups: Pachychoroid Pigment Epitheliopathy, Central Serous Chorioretinopathy, Pachychoroid Neovasculopathy, Polipoidal Choroidal Vasculopathy. Common Characteristics: Increased choroidal thickening, pathologically dilated veins in the Haller's layer (pachy-veins), thinning in Sattler's and choriocapilleris layers.

摘要

目的

对有关厚脉络膜疾病谱的文献进行系统综述。

方法

使用Medline数据库进行系统的文献检索。本文综述了四项与我们的检索直接相关的研究。

结果

结构和功能完整的脉络膜组织对视网膜功能至关重要。视网膜中央动脉负责供应视网膜2/3的内部部分,脉络膜静脉网络负责其余1/3的外部部分。脉络膜血流异常会导致视网膜中的光感受器功能障碍和光感受器死亡。用于脉络膜可视化的方法有吲哚菁绿血管造影(ICG血管造影)、如今常用的光学相干断层扫描(OCT)设备及其高级版本OCT血管造影。厚脉络膜疾病是4种不同疾病组的谱系。这些组本质上是疾病本身的阶段,因为前一组疾病严重程度的增加会使患者发展到下一组疾病。

结论

该谱系包括以下4种疾病组:厚脉络膜色素上皮病变、中心性浆液性脉络膜视网膜病变、厚脉络膜新生血管病变、息肉样脉络膜血管病变。共同特征:脉络膜增厚、Haller层病理性扩张的静脉(厚静脉)、Sattler层和脉络膜毛细血管层变薄。

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