加拿大艾伯塔省卡尔加里市急性髓系白血病的发病率：一项回顾性队列研究。
The incidence of acute myeloid leukemia in Calgary, Alberta, Canada: a retrospective cohort study.
作者信息
Shysh Andrea Christine, Nguyen Leonard Tu, Guo Maggie, Vaska Marcus, Naugler Christopher, Rashid-Kolvear Fariborz
机构信息
Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Calgary Laboratory Services, Calgary, AB, Canada.
出版信息
BMC Public Health. 2017 Aug 3;18(1):94. doi: 10.1186/s12889-017-4644-6.
BACKGROUND
The incidence rate of acute myeloid leukemia (AML) was determined in the Calgary Metropolitan Area, a major Canadian city.
METHODS
Data from all patients diagnosed with AML between January 1, 2011 and December 31, 2015 were retrieved from a single, centralized cancer cytogenetics laboratory for bone marrow samples, the sole diagnostic facility of its kind in Southern Alberta.
RESULTS
The calculated incidence rate was 2.79 cases per 100,000 person-years with a median age of 60, slightly lower than previously published data. The age-standardized incidence rate for Canada was 3.46 cases per 100,000 person-years. The higher value is reflective of Calgary's younger population compared to the rest of Canada. Higher male incidence and greatest incidence occurring at approximately the age of 85 is similar to data from other developed countries. The lower incidence rates and median age of diagnosis, in comparison with that of other high-income nations, may be due to differences in the proportion of aging citizens in the population.
CONCLUSION
This is the first published incidence rate of acute myeloid leukemia (AML) in Canada across all age groups.
背景
在加拿大主要城市卡尔加里都会区确定了急性髓系白血病（AML）的发病率。
方法
从一个单一的、集中的癌症细胞遗传学实验室获取了2011年1月1日至2015年12月31日期间所有诊断为AML的患者的数据，该实验室负责骨髓样本检测，是阿尔伯塔省南部唯一此类诊断机构。
结果
计算得出的发病率为每10万人年2.79例，中位年龄为60岁，略低于先前公布的数据。加拿大的年龄标准化发病率为每10万人年3.46例。较高的值反映出卡尔加里的人口比加拿大其他地区更年轻。男性发病率较高且最高发病率出现在大约85岁，这与其他发达国家的数据相似。与其他高收入国家相比，发病率较低和诊断时的中位年龄较低可能是由于人口中老龄公民比例的差异。
结论
这是加拿大首次公布的所有年龄组急性髓系白血病（AML）的发病率。
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