人类P-糖蛋白基因序列的染色体定位

Chromosomal location of human P-glycoprotein gene sequences.

作者信息

Bell D R, Trent J M, Willard H F, Riordan J R, Ling V

出版信息

Cancer Genet Cytogenet. 1987 Mar;25(1):141-8. doi: 10.1016/0165-4608(87)90169-5.

Abstract

Nonresponse to chemotherapy may result from the acquisition of multidrug resistance by malignant cells. Overexpression of the 170,000 dalton cell surface P-glycoprotein is associated with this phenotype and this appears to result from amplification of a multigene family coding for this protein. A cDNA encoding a conserved portion of P-glycoprotein has been cloned from hamster cells, and this was used in the present study to localize human P-glycoprotein gene sequences to chromosome 7q36.

摘要

对化疗无反应可能是由于恶性细胞获得了多药耐药性。170,000道尔顿细胞表面P-糖蛋白的过表达与这种表型相关，这似乎是由编码该蛋白的多基因家族扩增所致。从仓鼠细胞中克隆了编码P-糖蛋白保守部分的cDNA，并在本研究中用于将人类P-糖蛋白基因序列定位到染色体7q36。