夏科-马里-图思病各型及遗传性压力易感性神经病的不同神经超声表现。
Different nerve ultrasound patterns in charcot-marie-tooth types and hereditary neuropathy with liability to pressure palsies.
作者信息
Padua Luca, Coraci Daniele, Lucchetta Marta, Paolasso Ilaria, Pazzaglia Costanza, Granata Giuseppe, Cacciavillani Mario, Luigetti Marco, Manganelli Fiore, Pisciotta Chiara, Piscosquito Giuseppe, Pareyson Davide, Briani Chiara
机构信息
Department of Geriatrics, Neurosciences and Orthopaedics, Università Cattolica del Sacro Cuore, Rome, Italy.
Don Carlo Gnocchi Onlus Foundation, Piazzale Morandi 6, 20121, Milan, Italy.
出版信息
Muscle Nerve. 2018 Jan;57(1):E18-E23. doi: 10.1002/mus.25766. Epub 2017 Aug 24.
INTRODUCTION
Nerve ultrasound in Charcot-Marie-Tooth (CMT) disease has focused mostly on the upper limbs. We performed an evaluation of a large cohort of CMT patients in which we sonographically characterized nerve abnormalities in different disease types, ages, and nerves.
METHODS
Seventy patients affected by different CMT types and hereditary neuropathy with liability to pressure palsies (HNPP) were evaluated, assessing median, ulnar, fibular, tibial, and sural nerves bilaterally. Data were correlated with age.
RESULTS
Nerve dimensions were correlated with CMT type, age, and nerve site. Nerves were larger in demyelinating than in axonal neuropathies. Nerve involvement was symmetric.
DISCUSSION
CMT1 patients had larger nerves than did patients with other CMT types. Patients with HNPP showed enlargement at entrapment sites. Our study confirms the general symmetry of ultrasound nerve patterns in CMT. When compared with ultrasound studies of nerves of the upper limbs, evaluation of the lower limbs did not provide additional information. Muscle Nerve 57: E18-E23, 2018.
引言
夏科-马里-图斯（CMT）病的神经超声检查主要集中在上肢。我们对一大群CMT患者进行了评估，在其中我们通过超声对不同疾病类型、年龄和神经的神经异常进行了特征描述。
方法
对70例受不同CMT类型和易患压迫性麻痹的遗传性神经病（HNPP）影响的患者进行了评估，双侧评估正中神经、尺神经、腓总神经、胫神经和腓肠神经。数据与年龄相关。
结果
神经尺寸与CMT类型、年龄和神经部位相关。脱髓鞘性神经病中的神经比轴索性神经病中的神经更大。神经受累是对称的。
讨论
CMT1患者的神经比其他CMT类型的患者更大。HNPP患者在卡压部位出现增粗。我们的研究证实了CMT中超声神经模式的总体对称性。与上肢神经的超声研究相比，下肢评估未提供额外信息。《肌肉与神经》57: E18-E23, 2018。
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