Boston Children's Hospital, Department of Psychiatry, 300 Longwood Avenue, Boston, MA 02115, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.
Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA; McLean Hospital, Department of Psychiatry, 115 Mill Street, Belmont, MA 02478, USA.
Compr Psychiatry. 2017 Oct;78:31-37. doi: 10.1016/j.comppsych.2017.07.008. Epub 2017 Jul 20.
Previous research has demonstrated elevated rates of suicide attempts and ideation in individuals with psychosis. This study investigated rates and severity of suicidal behavior in youth with and at clinical high risk for psychosis, and examined the positive, negative, and disorganized symptoms associated with suicidal behaviors among the clinical high risk group.
Eighty-six youth ages 7-18 (n=21 non-clinical controls [NCC], n=40 clinical high risk [CHR], n=25 diagnosed psychotic disorder [PD]) were recruited. CHR and PD participants were identified using the Structured Interview for Prodromal Symptoms (SIPS) and Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (KSADS-PL). All participants completed the Suicide Behaviors Questionnaire-Revised (SBQ-R).
Findings indicated significantly higher levels of suicidal behavior among CHR and PD relative to NCC participants (F=7.64, p=0.001). 17.5% of CHR participants had previously attempted suicide. Dysphoric Mood and Odd Behavior or Appearance were significantly correlated with suicidal behavior severity among CHR youth.
Suicidal behavior was observed with greater frequency and severity in the CHR and PD groups than in the NCC group. CHR suicidal behavior severity was correlated most strongly with Dysphoric Mood and Odd Behavior or Appearance, a relationship which warrants further investigation.
先前的研究表明,精神病患者的自杀企图和意念发生率较高。本研究调查了有和处于精神病临床高风险的青年的自杀行为发生率和严重程度,并研究了临床高风险组中与自杀行为相关的阳性、阴性和紊乱症状。
招募了 86 名年龄在 7-18 岁的青年(n=21 名非临床对照组 [NCC],n=40 名临床高风险 [CHR],n=25 名诊断为精神病障碍 [PD])。CHR 和 PD 参与者是使用前驱症状结构化访谈(SIPS)和儿童青少年情感障碍和精神分裂症的诊断性访谈表(KSADS-PL)来识别的。所有参与者都完成了自杀行为问卷修订版(SBQ-R)。
研究结果表明,CHR 和 PD 参与者的自杀行为水平显著高于 NCC 参与者(F=7.64,p=0.001)。17.5%的 CHR 参与者曾有过自杀企图。抑郁心境和怪异行为或外貌与 CHR 青年的自杀行为严重程度显著相关。
与 NCC 组相比,CHR 和 PD 组的自杀行为更为频繁和严重。CHR 的自杀行为严重程度与抑郁心境和怪异行为或外貌的相关性最强,这一关系值得进一步研究。